Posthuman pits you as one of the last human survivors in a world where nature is reclaiming the planet and our evolved offspring are working to eradicate us. In the game, players are humans on a solitary journey to a promised safe house. This journey takes them through ten zones, with the zones being tile-based and randomly generated. As they travel, they encounter each other, other humans, and posthuman mutants. Encounters with mutants may inflict scars, and the more scars players have, the less human they are and the more posthuman they become. Defiant Expansion introduces the option of playing Posthuman with 5-6 players and includes new types of armour and home-made weapons.